학술논문

Case report: Regression of Glioblastoma after flavivirus infection
Document Type
article
Source
Frontiers in Medicine, Vol 10 (2023)
Subject
glioblastoma
flavivirus
oncolytic virus
ZIKV
DENV
immunovirotherapy
Medicine (General)
R5-920
Language
English
ISSN
2296-858X
Abstract
Glioblastoma is the most frequent and aggressive primary brain cancer. In preclinical studies, Zika virus, a flavivirus that triggers the death of glioblastoma stem-like cells. However, the flavivirus oncolytic activity has not been demonstrated in human patients. Here we report a glioblastoma patient who received the standard of care therapy, including surgical resection, radiotherapy and temozolomide. However, shortly after the tumor mass resection, the patient was clinically diagnosed with a typical arbovirus-like infection, during a Zika virus outbreak in Brazil. Following the infection resolution, the glioblastoma regressed, and no recurrence was observed. This clinical response continues 6 years after the glioblastoma initial diagnosis.