학술논문
IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
Document Type
article
Author
Sara Bisi; Stefano Marchesi; Abrar Rizvi; Davide Carra; Galina V. Beznoussenko; Ines Ferrara; Gianluca Deflorian; Alexander Mironov; Giovanni Bertalot; Federica Pisati; Amanda Oldani; Angela Cattaneo; Ghazaleh Saberamoli; Salvatore Pece; Giuseppe Viale; Angela Bachi; Claudio Tripodo; Giorgio Scita; Andrea Disanza
Source
Nature Communications, Vol 11, Iss 1, Pp 1-23 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if deleted, affects renal tubules morphogenesis in various organisms.