학술논문
Prognostic Value and Relative Cutoffs of Triglycerides Predicting Cardiovascular Outcome in a Large Regional‐Based Italian Database
Document Type
article
Author
Valérie Tikhonoff; Edoardo Casiglia; Agostino Virdis; Guido Grassi; Fabio Angeli; Marcello Arca; Carlo M. Barbagallo; Michele Bombelli; Federica Cappelli; Rosario Cianci; Arrigo F. G. Cicero; Massimo Cirillo; Pietro Cirillo; Raffaella Dell'oro; Lanfranco D'elia; Giovambattista Desideri; Claudio Ferri; Ferruccio Galletti; Loreto Gesualdo; Cristina Giannattasio; Guido Iaccarino; Francesca Mallamaci; Alessandro Maloberti; Stefano Masi; Maria Masulli; Alberto Mazza; Alessandro Mengozzi; Maria Lorenza Muiesan; Pietro Nazzaro; Paolo Palatini; Gianfranco Parati; Roberto Pontremoli; Fosca Quarti‐Trevano; Marcello Rattazzi; Gianpaolo Reboldi; Giulia Rivasi; Elisa Russo; Massimo Salvetti; Pier Luigi Temporelli; Giuliano Tocci; Andrea Ungar; Paolo Verdecchia; Francesca Viazzi; Massimo Volpe; Claudio Borghi
Source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Subject
Language
English
ISSN
2047-9980
Abstract
Background Despite longstanding epidemiologic data on the association between increased serum triglycerides and cardiovascular events, the exact level at which risk begins to rise is unclear. The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension has conceived a protocol aimed at searching for the prognostic cutoff value of triglycerides in predicting cardiovascular events in a large regional‐based Italian cohort. Methods and Results Among 14 189 subjects aged 18 to 95 years followed‐up for 11.2 (5.3–13.2) years, the prognostic cutoff value of triglycerides, able to discriminate combined cardiovascular events, was identified by means of receiver operating characteristic curve. The conventional (150 mg/dL) and the prognostic cutoff values of triglycerides were used as independent predictors in separate multivariable Cox regression models adjusted for age, sex, body mass index, total and high‐density lipoprotein cholesterol, serum uric acid, arterial hypertension, diabetes, chronic renal disease, smoking habit, and use of antihypertensive and lipid‐lowering drugs. During 139 375 person‐years of follow‐up, 1601 participants experienced cardiovascular events. Receiver operating characteristic curve showed that 89 mg/dL (95% CI, 75.8–103.3, sensitivity 76.6, specificity 34.1, P