학술논문
The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye
Document Type
article
Author
Fethi Gül; Umut Sabri Kasapoğlu; Mehmet Süleyman Sabaz; Pınar Ay; Burçin Doruk Oktay; Gülbahar Çalışkan; Nalan Demir; İsmet Sayan; Feyyaz Kabadayı; Gülsüm Altuntaş; Ayça Gümüş; Hülya Kırca; Deniz Şanlı; Fatma Acil; Andaç Dedeoğlu; Sedef Gülçin Ural; İrem Akın Şen; Eda Macit Aydın; Hakan Dayanır; Birgül Yelken; İlkay Ceylan; Osman Özcan Aydın; Güneş Eskidemir; Ahmet Aytekin; Melike Cengiz; Ülkü Arslan; Devrim Akdağ; Gülçin Hilal Alay; Esra Tekin; Volkan Yarar; Kemal Tolga Saracoğlu; Funda Gök; Volkan Alparslan; Verda Tuna; Murside Yıldız; Nimet Şenoğlu; Cenk Kıraklı; Süleyman Yıldırım; Kübra Saçar Kübüç; Ayşen Erer; Hamza Gültekin; Kezban Özmen Süner; Özge Kuzgun; Çağatay Erman Öztürk; Aydın Karahan; Okan Deveci; Mustafa Ay; Dilara Tüfek Öztan; Seda Banu Akıncı; Melahat Yalçın Solak; Süha Bozbay; Serhat Özçiftçi; Kamil Gönderen; Ahmet Oğuzhan Küçük; Berna Uyan; Gülseren Elay; Nazlıhan Boyacı; Mustafa Timurkaan; Ebru Karakoç; Lerzan Doğan; Erdem Yalçınkaya; Leyla Kazancıoğlu; Gül Erdal Dönmez; Barış Yılmaz; Dursun Fırat Ergül; Maruf Boran; Hüseyin Özkarakaş; Buğra Karakaş; Perihan Ergin Özcan; İlkay Anaklı; Mustafa Kemal Bayar; Didem Yüksel; Şükriye Akdağ; Özcan Pişkin; Sibel Temur; Selin Eyüpoğlu; Elvan Tekir Yılmaz; Gizem Zaim Avcı; Raziye Turan; Fatma Alkan Bayburt; Helin Şahintürk; Bülent Güçyetmez; Mustafa Muhlis Alparslan; Metin Yarıcı; Fatma Yıldırım; Abdulkadir Yektaş; Güçlü Yaman; Oktay Demirkıran; İsmail Cinel
Source
Balkan Medical Journal, Vol 40, Iss 6, Pp 435-444 (2023)
Subject
Language
English
ISSN
2146-3123
2146-3131
2146-3131
Abstract
Background:Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear.Aims:To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19.Study Design:Multicenter prospective observational clinical study.Methods:This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated.Results:As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores (p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) (p = 0.004).Conclusion:Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients.