학술논문
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
Document Type
article
Author
Sarah Kishinevsky; Tai Wang; Anna Rodina; Sun Young Chung; Chao Xu; John Philip; Tony Taldone; Suhasini Joshi; Mary L. Alpaugh; Alexander Bolaender; Simon Gutbier; Davinder Sandhu; Faranak Fattahi; Bastian Zimmer; Smit K. Shah; Elizabeth Chang; Carmen Inda; John Koren; Nathalie G. Saurat; Marcel Leist; Steven S. Gross; Venkatraman E. Seshan; Christine Klein; Mark J. Tomishima; Hediye Erdjument-Bromage; Thomas A. Neubert; Ronald C. Henrickson; Gabriela Chiosis; Lorenz Studer
Source
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
The early molecular events that ultimately lead to neuronal cell death in pathologies such as Parkinson’s disease are poorly understood. Here the authors use pluripotent stem-cell-derived human midbrain neurons and chemical biology tools to gain molecular level insight into the events induced by toxic and genetic stresses that mimic those occurring during neurodegeneration.