학술논문
Fathers’ preconception smoking and offspring DNA methylation
Document Type
article
Author
Negusse Tadesse Kitaba; Gerd Toril Mørkve Knudsen; Ane Johannessen; Faisal I. Rezwan; Andrei Malinovschi; Anna Oudin; Bryndis Benediktsdottir; David Martino; Francisco Javier Callejas González; Leopoldo Palacios Gómez; Mathias Holm; Nils Oskar Jõgi; Shyamali C. Dharmage; Svein Magne Skulstad; Sarah H. Watkins; Matthew Suderman; Francisco Gómez-Real; Vivi Schlünssen; Cecilie Svanes; John W. Holloway
Source
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Subject
Language
English
ISSN
1868-7083
Abstract
Abstract Background Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We aim to identify epigenetic marks in offspring associated with father’s preconception smoking. Methods We conducted epigenome-wide association studies (EWAS) in the RHINESSA cohort (7–50 years) on father’s any preconception smoking (n = 875 offspring) and father’s pubertal onset smoking