학술논문
Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites
Document Type
article
Author
David Guerrero; Hoa Thi My Vo; Chanthap Lon; Jennifer A. Bohl; Sreynik Nhik; Sophana Chea; Somnang Man; Sokunthea Sreng; Andrea R. Pacheco; Sokna Ly; Rathanak Sath; Sokchea Lay; Dorothée Missé; Rekol Huy; Rithea Leang; Hok Kry; Jesus G. Valenzuela; Fabiano Oliveira; Tineke Cantaert; Jessica E. Manning
Source
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Vector-borne pathogens are known to elicit immune response upon mosquito biting the host which is critically linked to the establishment of infection and pathogenesis of disease, yet the impact of the mosquito bite itself is not immunologically well-appreciated. Here the authors characterize the immune response to the mosquito vector Aedes aegypti in a controlled human in vivo challenge model and show the induction of a range of immune pathways and cell types.