학술논문
Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression
Document Type
article
Author
Moh’d Mohanad Al-Dabet; Khurrum Shahzad; Ahmed Elwakiel; Alba Sulaj; Stefan Kopf; Fabian Bock; Ihsan Gadi; Silke Zimmermann; Rajiv Rana; Shruthi Krishnan; Dheerendra Gupta; Jayakumar Manoharan; Sameen Fatima; Sumra Nazir; Constantin Schwab; Ronny Baber; Markus Scholz; Robert Geffers; Peter Rene Mertens; Peter P. Nawroth; John H. Griffin; Maria Keller; Chris Dockendorff; Shrey Kohli; Berend Isermann
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Persistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyperglycemic memory, the suppression of which improves hyperglycemic memory and renal function.