학술논문
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
Document Type
article
Author
Lúcia Moreira-Teixeira; Philippa J. Stimpson; Evangelos Stavropoulos; Sabelo Hadebe; Probir Chakravarty; Marianna Ioannou; Iker Valle Aramburu; Eleanor Herbert; Simon L. Priestnall; Alejandro Suarez-Bonnet; Jeremy Sousa; Kaori L. Fonseca; Qian Wang; Sergo Vashakidze; Paula Rodríguez-Martínez; Cristina Vilaplana; Margarida Saraiva; Venizelos Papayannopoulos; Anne O’Garra
Source
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
GM-CSF is involved in control over M. tuberculosis infection. Here the authors show that GM-CSF reduces type 1 interferon driven neutrophil recruitment, NETosis and bacterial growth in the lungs of infected mice, and provide evidence that this NETosis occurs in infected humans who are not responsive to antibiotic therapy.