학술논문
Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome.
Document Type
article
Author
Eva C Schulte; Katharina Schramm; Claudia Schurmann; Peter Lichtner; Christian Herder; Michael Roden; Christian Gieger; Annette Peters; Claudia Trenkwalder; Birgit Högl; Birgit Frauscher; Klaus Berger; Ingo Fietze; Nadine Gross; Karin Stiasny-Kolster; Wolfgang Oertel; Cornelius G Bachmann; Walter Paulus; Alexander Zimprich; Henry Völzke; Ulf Schminke; Matthias Nauck; Thomas Illig; Thomas Meitinger; Bertram Müller-Myhsok; Holger Prokisch; Juliane Winkelmann
Source
PLoS ONE, Vol 9, Iss 5, p e98092 (2014)
Subject
Language
English
ISSN
1932-6203
Abstract
Restless legs syndrome (RLS) is a common neurologic disorder characterized by nightly dysesthesias affecting the legs primarily during periods of rest and relieved by movement. RLS is a complex genetic disease and susceptibility factors in six genomic regions have been identified by means of genome-wide association studies (GWAS). For some complex genetic traits, expression quantitative trait loci (eQTLs) are enriched among trait-associated single nucleotide polymorphisms (SNPs). With the aim of identifying new genetic susceptibility factors for RLS, we assessed the 332 best-associated SNPs from the genome-wide phase of the to date largest RLS GWAS for cis-eQTL effects in peripheral blood from individuals of European descent. In 740 individuals belonging to the KORA general population cohort, 52 cis-eQTLs with pnominal