학술논문
A human antibody against Zika virus crosslinks the E protein to prevent infection
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
The human monoclonal antibody ZIKV-117 has demonstrated therapeutic potential against Zika while showing no cross-reactivity to other flaviviruses. Here the authors present a cryo-EM structure of the ZIKV strain H/PF/2013 in complex with the ZIKV-117 Fab, shedding light on its neutralization mechanism.