학술논문
Use of Radiology, D-Dimer, and Mean Platelet Volume Combination as a Prognostic Marker in Hospitalized Coronavirus Disease-19 Patients
Document Type
article
Author
Nagihan Durmus Kocak; Ozlem Oruc; Sibel Boga; Cem Acar; Murat Kavas; Selma Aydogan Eroglu; Baran Gundogus; Ozlem Sogukpinar; Sumeyye Bekir; Aysem Askim Oztin Guven; Makbule Ozlem Akbay; Sibel Arinc; Dildar Duman; Huriye Berk Takir; Feride Yaman; Fatma Ozbaki; Esin Sonkaya; Esra Usta Bulbul; Dilem Anil Tokyay; Lale Dagyildizi; Ulku Aka Akturk; Selahattin Oztas; Dilek Ernam; Gokay Gungor; Nalan Adiguzel; Tekin Yildiz; Ozlem Yazicioglu Mocin; Hakan Gunen; Reyhan Yildiz; Tulin Sevim; Tulay Torun
Source
Frontiers in Medicine, Vol 8 (2022)
Subject
Language
English
ISSN
2296-858X
Abstract
IntroductionThe search for biomarkers that could help in predicting disease prognosis in the Coronavirus Disease-2019 (COVID-19) outbreak is still high on the agenda.ObjectiveTo find out the efficacy of D-dimer and mean platelet volume (MPV) combination as a prognostic marker in hospitalized COVID-19 patients with bilateral infiltration.Materials and MethodsStudy design: Retrospective observational cohort. Patients who were presented to our hospital between March 16, 2020 and June 07, 2020 were reviewed retrospectively. The primary outcome of the study was specified as the need for intensive care, while the secondary outcomes were duration of treatment and hospitalization. Receiver operator curve (ROC) analyzes were carried out to assess the efficacy of D-dimer and MPV parameters as prognostic markers.ResultsBetween the mentioned dates, 575 of 1,564 patients were found to be compatible with COVID-19, and the number of patients who were included in the study was 306. The number of patients who developed the need for intensive care was 40 (13.1%). For serum D-dimer levels in assessing the need for intensive care, the area under the curve (AUC) was found to be 0.707 (95% CI: 0.620–0.794). The AUC for MPV was 0.694 (95% CI: 0.585–0.803), when D-dimer was ≥1.0 mg/L. When patients with a D-dimer level of ≥1.0 mg/L were divided into two groups considering the MPV cut-off value as 8.1, the rate of intensive care transport was found to be significantly higher in patients with an MPV of ≥8.1 fL compared to those with an MPV of