학술논문
Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort
Document Type
article
Author
Source
Hypertension in Pregnancy, Vol 39, Iss 3, Pp 326-335 (2020)
Subject
Language
English
ISSN
1064-1955
1525-6065
10641955
1525-6065
10641955
Abstract
Objective To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension. Methods Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls. Results Syndecan-1 concentrations were lower at 26–27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumin:creatinine ratio were also associated with development of superimposed preeclampsia. Conclusion Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.