학술논문
Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants
Document Type
article
Author
Source
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2399-3642
Abstract
Here, the authors report a genome-wide association analysis for corneal resistance factor (CRF), a measure of corneal biomechanical properties relevant to a number of corneal diseases. They identify 135 loci associated with CRF and use fine-mapping and ATAC-seq in human cornea cell lines to identify putative causal variants affecting gene expression.