학술논문
Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study
Document Type
article
Author
Jose Bernal; Stefanie Schreiber; Inga Menze; Anna Ostendorf; Malte Pfister; Jonas Geisendörfer; Aditya Nemali; Anne Maass; Renat Yakupov; Oliver Peters; Lukas Preis; Luisa Schneider; Ana Lucia Herrera; Josef Priller; Eike Jakob Spruth; Slawek Altenstein; Anja Schneider; Klaus Fliessbach; Jens Wiltfang; Björn H. Schott; Ayda Rostamzadeh; Wenzel Glanz; Katharina Buerger; Daniel Janowitz; Michael Ewers; Robert Perneczky; Boris-Stephan Rauchmann; Stefan Teipel; Ingo Kilimann; Christoph Laske; Matthias H. Munk; Annika Spottke; Nina Roy; Laura Dobisch; Peter Dechent; Klaus Scheffler; Stefan Hetzer; Steffen Wolfsgruber; Luca Kleineidam; Matthias Schmid; Moritz Berger; Frank Jessen; Miranka Wirth; Emrah Düzel; Gabriel Ziegler
Source
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
1758-9193
Abstract
Abstract Background White matter hyperintensities (WMH) in subjects across the Alzheimer’s disease (AD) spectrum with minimal vascular pathology suggests that amyloid pathology—not just arterial hypertension—impacts WMH, which in turn adversely influences cognition. Here we seek to determine the effect of both hypertension and Aβ positivity on WMH, and their impact on cognition. Methods We analysed data from subjects with a low vascular profile and normal cognition (NC), subjective cognitive decline (SCD), and amnestic mild cognitive impairment (MCI) enrolled in the ongoing observational multicentre DZNE Longitudinal Cognitive Impairment and Dementia Study (n = 375, median age 70.0 [IQR 66.0, 74.4] years; 178 female; NC/SCD/MCI 127/162/86). All subjects underwent a rich neuropsychological assessment. We focused on baseline memory and executive function—derived from multiple neuropsychological tests using confirmatory factor analysis—, baseline preclinical Alzheimer’s cognitive composite 5 (PACC5) scores, and changes in PACC5 scores over the course of three years (ΔPACC5). Results Subjects with hypertension or Aβ positivity presented the largest WMH volumes (p FDR