학술논문
Necrotizing soft tissue infections in critically ill neutropenic patients: a French multicentre retrospective cohort study
Document Type
article
Author
Romain Arrestier; Anis Chaba; Asma Mabrouki; Clément Saccheri; Emmanuel Canet; Marc Pineton de Chambrun; Annabelle Stoclin; Muriel Picard; Florent Wallet; François Perier; Matthieu Turpin; Laurent Argaud; Maxens Decavèle; Nahéma Issa; Cyril Cadoz; Kada Klouche; Johana Cohen; Djamel Mokart; Julien Grouille; Tomas Urbina; Camille Hua; Olivier Chosidow; Armand Mekontso-Dessap; Elie Azoulay; Nicolas de Prost
Source
Annals of Intensive Care, Vol 13, Iss 1, Pp 1-9 (2023)
Subject
Language
English
ISSN
2110-5820
86050885
86050885
Abstract
Abstract Background Necrotizing soft tissue infections (NSTIs) are rare life-threatening bacterial infections. Few data are available regarding neutropenic patients with NSTIs. Our objectives were to describe the characteristics and management of neutropenic patients with NSTIs in intensive care units (ICUs). We conducted a retrospective multicentre cohort study in 18 ICUs between 2011 and 2021. Patients admitted with NSTIs and concomitant neutropenia at diagnosis were included and compared to non-neutropenic patients with NSTIs. The relationship between therapeutic interventions and outcomes was assessed using Cox regression and propensity score matching. Results 76 neutropenic patients were included and compared to 165 non-neutropenic patients. Neutropenic patients were younger (54 ± 14 vs 60 ± 13 years, p = 0.002) and had less lower limb (44.7% vs 70.9%, p