학술논문
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
Document Type
article
Author
Katherine A. Davies; Cheree Fitzgibbon; Samuel N. Young; Sarah E. Garnish; Wayland Yeung; Diane Coursier; Richard W. Birkinshaw; Jarrod J. Sandow; Wil I. L. Lehmann; Lung-Yu Liang; Isabelle S. Lucet; James D. Chalmers; Wayne M. Patrick; Natarajan Kannan; Emma J. Petrie; Peter E. Czabotar; James M. Murphy
Source
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
The necroptotic cell death pathway involves signaling through pseudokinases. Here the authors define the structural determinants of species specificity in necroptosis signaling mediated by the essential necroptotic effector pseudokinase, Mixed Lineage Kinase Domain-Like (MLKL).