학술논문
Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA3 levels and increases sensitivity to platinum agents suggesting a therapeutic route.