학술논문
Plasma extracellular vesicles reveal early molecular differences in amyloid positive patients with early-onset mild cognitive impairment
Document Type
article
Author
Amanda Cano; Ester Esteban-de-Antonio; Mireia Bernuz; Raquel Puerta; Pablo García-González; Itziar de Rojas; Claudia Olivé; Alba Pérez-Cordón; Laura Montrreal; Raúl Núñez-Llaves; Óscar Sotolongo-Grau; Emilio Alarcón-Martín; Sergi Valero; Montserrat Alegret; Elvira Martín; Pamela V. Martino-Adami; Miren Ettcheto; Antonio Camins; Assumpta Vivas; Marta Gomez-Chiari; Miguel Ángel Tejero; Adelina Orellana; Lluís Tárraga; Marta Marquié; Alfredo Ramírez; Mercè Martí; María Isabel Pividori; Mercè Boada; Agustín Ruíz
Source
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-19 (2023)
Subject
Language
English
ISSN
1477-3155
Abstract
Highlights The pEVs proteome revealed early molecular differences between EOMCI Aβ( +) and Aβ(-) subjects. Olink© neurology proteins from pEVs of EOMCI Aβ( +) patients exhibited a strong negative correlation with CSF p-tau181. The levels of pEVs and CSF Olink© proteins correlated with CSF p-tau181 levels and age. Brain MRI characteristics of EOMCI Aβ( +) patients correlated with pEVs protein levels. pEVs biomarkers only linked early signs of inflammation to brain atrophy in EOMCI Aβ( +) individuals. The correlation of cognitive status and pEVs biomarkers differed between EOMCI Aβ( +) and Aβ(-) patients.