학술논문
Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study
Document Type
article
Author
Gaetano Scaramuzzo; Lorenzo Gamberini; Tommaso Tonetti; Gianluca Zani; Irene Ottaviani; Carlo Alberto Mazzoli; Chiara Capozzi; Emanuela Giampalma; Maria Letizia Bacchi Reggiani; Elisabetta Bertellini; Andrea Castelli; Irene Cavalli; Davide Colombo; Federico Crimaldi; Federica Damiani; Maurizio Fusari; Emiliano Gamberini; Giovanni Gordini; Cristiana Laici; Maria Concetta Lanza; Mirco Leo; Andrea Marudi; Giuseppe Nardi; Raffaella Papa; Antonella Potalivo; Emanuele Russo; Stefania Taddei; Guglielmo Consales; Iacopo Cappellini; Vito Marco Ranieri; Carlo Alberto Volta; Claude Guerin; Savino Spadaro; The ICU-RER COVID-19 Collaboration
Source
Annals of Intensive Care, Vol 11, Iss 1, Pp 1-10 (2021)
Subject
Language
English
ISSN
2110-5820
Abstract
Abstract Background Prone positioning (PP) has been used to improve oxygenation in patients affected by the SARS-CoV-2 disease (COVID-19). Several mechanisms, including lung recruitment and better lung ventilation/perfusion matching, make a relevant rational for using PP. However, not all patients maintain the oxygenation improvement after returning to supine position. Nevertheless, no evidence exists that a sustained oxygenation response after PP is associated to outcome in mechanically ventilated COVID-19 patients. We analyzed data from 191 patients affected by COVID-19-related acute respiratory distress syndrome undergoing PP for clinical reasons. Clinical history, severity scores and respiratory mechanics were analyzed. Patients were classified as responders (≥ median PaO2/FiO2 variation) or non-responders (