학술논문
Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry
Document Type
article
Author
Pedro David Wendel-Garcia; André Moser; Marie-Madlen Jeitziner; Hernán Aguirre-Bermeo; Pedro Arias-Sanchez; Janina Apolo; Ferran Roche-Campo; Diego Franch-Llasat; Gian-Reto Kleger; Claudia Schrag; Urs Pietsch; Miodrag Filipovic; Sascha David; Klaus Stahl; Souad Bouaoud; Amel Ouyahia; Patricia Fodor; Pascal Locher; Martin Siegemund; Nuria Zellweger; Sara Cereghetti; Peter Schott; Gianfilippo Gangitano; Maddalena Alessandra Wu; Mario Alfaro-Farias; Gerardo Vizmanos-Lamotte; Hatem Ksouri; Nadine Gehring; Emanuele Rezoagli; Fabrizio Turrini; Herminia Lozano-Gómez; Andrea Carsetti; Raquel Rodríguez-García; Bernd Yuen; Anja Baltussen Weber; Pedro Castro; Jesus Oscar Escos-Orta; Alexander Dullenkopf; Maria C. Martín-Delgado; Theodoros Aslanidis; Marie-Helene Perez; Frank Hillgaertner; Samuele Ceruti; Marilene Franchitti Laurent; Julien Marrel; Riccardo Colombo; Marcus Laube; Alberto Fogagnolo; Michael Studhalter; Tobias Wengenmayer; Emiliano Gamberini; Christian Buerkle; Philipp K. Buehler; Stefanie Keiser; Muhammed Elhadi; Jonathan Montomoli; Philippe Guerci; Thierry Fumeaux; Reto A. Schuepbach; Stephan M. Jakob; Yok-Ai Que; Matthias Peter Hilty; the RISC-19-ICU Investigators
Source
Critical Care, Vol 26, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
1364-8535
Abstract
Abstract Background It remains elusive how the characteristics, the course of disease, the clinical management and the outcomes of critically ill COVID-19 patients admitted to intensive care units (ICU) worldwide have changed over the course of the pandemic. Methods Prospective, observational registry constituted by 90 ICUs across 22 countries worldwide including patients with a laboratory-confirmed, critical presentation of COVID-19 requiring advanced organ support. Hierarchical, generalized linear mixed-effect models accounting for hospital and country variability were employed to analyse the continuous evolution of the studied variables over the pandemic. Results Four thousand forty-one patients were included from March 2020 to September 2021. Over this period, the age of the admitted patients (62 [95% CI 60–63] years vs 64 [62–66] years, p