학술논문

Fat digestion and absorption in the adrenalectomized rat
Document Type
article
Source
Journal of Lipid Research, Vol 7, Iss 2, Pp 236-241 (1966)
Subject
hypoadrenal
rat
fat malabsorption
lipolysis
gastric emptying
fatty acid activation
Biochemistry
QD415-436
Language
English
ISSN
0022-2275
Abstract
Malabsorption of fat in the adrenalectomized rat has been confirmed. The criteria for adrenal hypofunction were more rigorous than in previous studies. The malabsorption is not due to impaired intestinal lipolysis or inadequate intestinal intracellular glyceride synthesis. Delayed gastric emptying is probably secondary to the malabsorption rather than a cause. It is postulated that impaired intestinal fatty acid activation may be the key defect and that in some way this inhibits fatty acid transport across the mucosal membrane.