학술논문
Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
Document Type
article
Author
Pierre Hirsch; Yanyan Zhang; Ruoping Tang; Virginie Joulin; Hélène Boutroux; Elodie Pronier; Hannah Moatti; Pascale Flandrin; Christophe Marzac; Dominique Bories; Fanny Fava; Hayat Mokrani; Aline Betems; Florence Lorre; Rémi Favier; Frédéric Féger; Mohamad Mohty; Luc Douay; Ollivier Legrand; Chrystèle Bilhou-Nabera; Fawzia Louache; François Delhommeau
Source
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Pre-leukaemic clones, together with the propensity to cause disease in mice, are characterized by appearing early in myeloid leukaemia and being found at relapse. Here, the authors identify clones in human samples and find that they are characterized by hierarchically organized genetic lesions, which can be used to track evolution of the disease.