학술논문
Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B
Document Type
article
Author
Maximilian Y. Deng; Dominik Sturm; Elke Pfaff; Martin Sill; Damian Stichel; Gnana Prakash Balasubramanian; Stephan Tippelt; Christof Kramm; Andrew M. Donson; Adam L. Green; Chris Jones; Jens Schittenhelm; Martin Ebinger; Martin U. Schuhmann; Barbara C. Jones; Cornelis M. van Tilburg; Andrea Wittmann; Andrey Golanov; Marina Ryzhova; Jonas Ecker; Till Milde; Olaf Witt; Felix Sahm; David Reuss; David Sumerauer; Josef Zamecnik; Andrey Korshunov; Andreas von Deimling; Stefan M. Pfister; David T. W. Jones
Source
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies but their origin are still unclear. Here, the authors define the genomic, epigenetic and transcriptional landscape of 32 RIGs cases.