학술논문
Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies
Document Type
article
Author
Source
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract To quantify the association between maternal uric acid levels and pre-eclampsia risk in a large collection of primigravid women. A case–control study (1365 cases of pre-eclampsia and 1886 normotensive controls) was conducted. Pre-eclampsia was defined as blood pressure ≥ 140/90 mmHg and proteinuria ≥ 300 mg/24 h. Sub-outcome analysis included early, intermediate, and late pre-eclampsia. Multivariable analysis for pre-eclampsia and its sub-outcomes was conducted using binary and multinomial logistic regression, respectively. Additionally, a systematic review and meta-analysis of cohort studies measuring uric acid levels