학술논문
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Document Type
article
Author
Xia Jiang; Paul F. O’Reilly; Hugues Aschard; Yi-Hsiang Hsu; J. Brent Richards; Josée Dupuis; Erik Ingelsson; David Karasik; Stefan Pilz; Diane Berry; Bryan Kestenbaum; Jusheng Zheng; Jianan Luan; Eleni Sofianopoulou; Elizabeth A. Streeten; Demetrius Albanes; Pamela L. Lutsey; Lu Yao; Weihong Tang; Michael J. Econs; Henri Wallaschofski; Henry Völzke; Ang Zhou; Chris Power; Mark I. McCarthy; Erin D. Michos; Eric Boerwinkle; Stephanie J. Weinstein; Neal D. Freedman; Wen-Yi Huang; Natasja M. Van Schoor; Nathalie van der Velde; Lisette C. P. G. M. de Groot; Anke Enneman; L. Adrienne Cupples; Sarah L. Booth; Ramachandran S. Vasan; Ching-Ti Liu; Yanhua Zhou; Samuli Ripatti; Claes Ohlsson; Liesbeth Vandenput; Mattias Lorentzon; Johan G. Eriksson; M. Kyla Shea; Denise K. Houston; Stephen B. Kritchevsky; Yongmei Liu; Kurt K. Lohman; Luigi Ferrucci; Munro Peacock; Christian Gieger; Marian Beekman; Eline Slagboom; Joris Deelen; Diana van Heemst; Marcus E. Kleber; Winfried März; Ian H. de Boer; Alexis C. Wood; Jerome I. Rotter; Stephen S. Rich; Cassianne Robinson-Cohen; Martin den Heijer; Marjo-Riitta Jarvelin; Alana Cavadino; Peter K. Joshi; James F. Wilson; Caroline Hayward; Lars Lind; Karl Michaëlsson; Stella Trompet; M. Carola Zillikens; Andre G. Uitterlinden; Fernando Rivadeneira; Linda Broer; Lina Zgaga; Harry Campbell; Evropi Theodoratou; Susan M. Farrington; Maria Timofeeva; Malcolm G. Dunlop; Ana M. Valdes; Emmi Tikkanen; Terho Lehtimäki; Leo-Pekka Lyytikäinen; Mika Kähönen; Olli T. Raitakari; Vera Mikkilä; M. Arfan Ikram; Naveed Sattar; J. Wouter Jukema; Nicholas J. Wareham; Claudia Langenberg; Nita G. Forouhi; Thomas E. Gundersen; Kay-Tee Khaw; Adam S. Butterworth; John Danesh; Timothy Spector; Thomas J. Wang; Elina Hyppönen; Peter Kraft; Douglas P. Kiel
Source
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Vitamin D deficiency is associated with multiple human pathologic conditions. In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune diseases.