학술논문
Case report: Ponatinib as a bridge to CAR-T cells and subsequent maintenance in a patient with relapsed/refractory Philadelphia-like acute lymphoblastic leukemia
Document Type
article
Author
Fabio Giglio; Edoardo Campodonico; Francesca Lorentino; Maddalena Noviello; Elisabetta Xue; Raffaella Greco; Lorenzo Lazzari; Alessandro Bruno; Maria Teresa Lupo Stanghellini; Matteo Giovanni Carrabba; Roberta La Starza; Monica Casucci; Chiara Bonini; Sabina Chiaretti; Jacopo Peccatori; Robin Foà; Fabio Ciceri
Source
Frontiers in Oncology, Vol 12 (2023)
Subject
Language
English
ISSN
2234-943X
Abstract
Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) constitutes a heterogeneous subset of ALL with a uniformly unfavorable prognosis. The identification of mutations amenable to treatment with tyrosine kinase-inhibitors (TKIs) represents a promising field of investigation. We report the case of a young patient affected by relapsed/refractory Ph-like ALL treated with chimeric antigen receptor T (CAR-T) cells after successful bridging with compassionate-use ponatinib and low-dose prednisone. We restarted low-dose ponatinib maintenance three months later. Twenty months later, measurable residual disease negativity and B-cell aplasia persist. To the best of our knowledge, this is the first case reporting the use of ponatinib in Ph-like ALL as a bridge to and maintenance after CAR-T cell therapy.