학술논문
Loss of immune tolerance to IL-2 in type 1 diabetes
Document Type
article
Author
Louis Pérol; John M. Lindner; Pamela Caudana; Nicolas Gonzalo Nunez; Audrey Baeyens; Andrea Valle; Christine Sedlik; Delphine Loirat; Olivier Boyer; Alain Créange; José Laurent Cohen; Ute Christine Rogner; Jun Yamanouchi; Martine Marchant; Xavier Charles Leber; Meike Scharenberg; Marie-Claude Gagnerault; Roberto Mallone; Manuela Battaglia; Pere Santamaria; Agnès Hartemann; Elisabetta Traggiai; Eliane Piaggio
Source
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.