학술논문
A protein tertiary structure mimetic modulator of the Hippo signalling pathway
Document Type
article
Author
Hélène Adihou; Ranganath Gopalakrishnan; Tim Förster; Stéphanie M. Guéret; Raphael Gasper; Stefan Geschwindner; Carmen Carrillo García; Hacer Karatas; Ajaybabu V. Pobbati; Mercedes Vazquez‐Chantada; Paul Davey; Carola M. Wassvik; Jeremy Kah Sheng Pang; Boon Seng Soh; Wanjin Hong; Elisabetta Chiarparin; Dennis Schade; Alleyn T. Plowright; Eric Valeur; Malin Lemurell; Tom N. Grossmann; Herbert Waldmann
Source
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEAD:VGL4 interaction in vitro and in cells.