학술논문
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response
Document Type
article
Author
Dimitra Georgopoulou; Maurizio Callari; Oscar M. Rueda; Abigail Shea; Alistair Martin; Agnese Giovannetti; Fatime Qosaj; Ali Dariush; Suet-Feung Chin; Larissa S. Carnevalli; Elena Provenzano; Wendy Greenwood; Giulia Lerda; Elham Esmaeilishirazifard; Martin O’Reilly; Violeta Serra; Dario Bressan; IMAXT Consortium; Gordon B. Mills; H. Raza Ali; Sabina S. Cosulich; Gregory J. Hannon; Alejandra Bruna; Carlos Caldas
Source
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2041-1723
06795129
06795129
Abstract
The heterogeneity of breast cancer has a major role in drug response and resistance. In this study, the authors use patient-derived tumour xenografts as a platform for drug testing and correlation with single-cell proteomic phenotypes characterized by mass cytometry.