학술논문
Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Jonathan Sulc et al. use principal component analysis and Mendelian randomization to conduct a comprehensive analysis of 14 body morphology metrics using data from the UK Biobank. Their results suggest that body size and adiposity have distinct impacts on obesity-related outcomes and highlight a BMI-neutral component affecting body fat distribution, providing further insight into the genetic basis of body shape and its consequences on human health and lifestyle.