학술논문
Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
An efficient vaccine for human metapneumovirus (hMPV) will likely rely on neutralizing antibodies against the fusion protein (F). Here, the authors determine the crystal structure of pre-fusion-stabilized hMPV F and identify a dense glycan shield that affects generation of neutralizing antibodies.