학술논문

Extreme immunotherapy: emergency immunology to defeat pandemics
Document Type
article
Source
Molecular Medicine, Vol 27, Iss 1, Pp 1-6 (2021)
Subject
COVID-19
SARS-CoV-2
Pandemic
Immunotherapy
Emergency
Therapeutics. Pharmacology
RM1-950
Biochemistry
QD415-436
Language
English
ISSN
1076-1551
1528-3658
Abstract
Abstract The ongoing global COVID-19 pandemic has thrown into sharp relief the gap between modern biology’s ability to investigate and respond to a novel pathogen and modern medicine’s ability to marshal effective front-line interventions to limit its immediate health impact. While we have witnessed the rapid development of innovative vaccines against SARS-CoV-2 using novel molecular platforms, these have yet to alter the pandemic’s long-term trajectory in all but a handful of high-income countries. Health workers at the clinical front lines have little more in their clinical armamentarium than was available a century ago—chiefly oxygen and steroids—and yet advances in modern immunology and immunotherapeutics suggest an underuse of extant and effective, if unorthodox, therapies, which we now call “Extreme Immunotherapies for Pandemics (EIPs).”