학술논문
Phenome-wide association studies across large population cohorts support drug target validation
Document Type
article
Author
Dorothée Diogo; Chao Tian; Christopher S. Franklin; Mervi Alanne-Kinnunen; Michael March; Chris C. A. Spencer; Ciara Vangjeli; Michael E. Weale; Hannele Mattsson; Elina Kilpeläinen; Patrick M. A. Sleiman; Dermot F. Reilly; Joshua McElwee; Joseph C. Maranville; Arnaub K. Chatterjee; Aman Bhandari; Khanh-Dung H. Nguyen; Karol Estrada; Mary-Pat Reeve; Janna Hutz; Nan Bing; Sally John; Daniel G. MacArthur; Veikko Salomaa; Samuli Ripatti; Hakon Hakonarson; Mark J. Daly; Aarno Palotie; David A. Hinds; Peter Donnelly; Caroline S. Fox; Aaron G. Day-Williams; Robert M. Plenge; Heiko Runz
Source
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Testing the association between genetic variants and a range of phenotypes can assist drug development. Here, in a phenome-wide association study in up to 697,815 individuals, Diogo et al. identify genotype–phenotype associations predicting efficacy, alternative indications or adverse drug effects.