학술논문
A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation
Document Type
article
Author
Giulietta S. Monasso; Thanh T. Hoang; Giulia Mancano; Sílvia Fernández-Barrés; John Dou; Vincent W.V. Jaddoe; Christian M. Page; Laura Johnson; Mariona Bustamante; Kelly M. Bakulski; Siri E. Håberg; Per M. Ueland; Thomas Battram; Simon K. Merid; Erik Melén; Doretta Caramaschi; Leanne K. Küpers; Jordi Sunyer; Wenche Nystad; Sandra G. Heil; Rebecca J. Schmidt; Martine Vrijheid; Gemma C. Sharp; Stephanie J. London; Janine F. Felix
Source
Epigenetics, Vol 18, Iss 1 (2023)
Subject
Language
English
ISSN
1559-2294
1559-2308
15592294
1559-2308
15592294
Abstract
Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentrations in mothers during pregnancy (n = 2,420) or cord blood (n = 1,029), with cord blood DNA methylation. Maternal and newborn vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs, respectively (False Discovery Rate P-value