학술논문
Proteome-wide Mendelian randomization identifies causal plasma proteins in lung cancer
Document Type
article
Author
Source
iScience, Vol 27, Iss 2, Pp 108985- (2024)
Subject
Language
English
ISSN
2589-0042
62499610
62499610
Abstract
Summary: Plasma proteins are promising biomarkers and potential drug targets in lung cancer. To evaluate the causal association between plasma proteins and lung cancer, we performed proteome-wide Mendelian randomization meta-analysis (PW-MR-meta) based on lung cancer genome-wide association studies (GWASs), protein quantitative trait loci (pQTLs) of 4,719 plasma proteins in deCODE and 4,775 in Fenland. Further, causal-protein risk score (CPRS) was developed based on causal proteins and validated in the UK Biobank. 270 plasma proteins were identified using PW-MR meta-analysis, including 39 robust causal proteins (both FDR-q