학술논문
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression
Document Type
article
Author
Jing Liu; Daniela Ottaviani; Meriem Sefta; Céline Desbrousses; Elodie Chapeaublanc; Rosario Aschero; Nanor Sirab; Fabiana Lubieniecki; Gabriela Lamas; Laurie Tonon; Catherine Dehainault; Clément Hua; Paul Fréneaux; Sacha Reichman; Narjesse Karboul; Anne Biton; Liliana Mirabal-Ortega; Magalie Larcher; Céline Brulard; Sandrine Arrufat; André Nicolas; Nabila Elarouci; Tatiana Popova; Fariba Némati; Didier Decaudin; David Gentien; Sylvain Baulande; Odette Mariani; Florent Dufour; Sylvain Guibert; Céline Vallot; Livia Lumbroso-Le Rouic; Alexandre Matet; Laurence Desjardins; Guillem Pascual-Pasto; Mariona Suñol; Jaume Catala-Mora; Genoveva Correa Llano; Jérôme Couturier; Emmanuel Barillot; Paula Schaiquevich; Marion Gauthier-Villars; Dominique Stoppa-Lyonnet; Lisa Golmard; Claude Houdayer; Hervé Brisse; Isabelle Bernard-Pierrot; Eric Letouzé; Alain Viari; Simon Saule; Xavier Sastre-Garau; François Doz; Angel M. Carcaboso; Nathalie Cassoux; Celio Pouponnot; Olivier Goureau; Guillermo Chantada; Aurélien de Reyniès; Isabelle Aerts; François Radvanyi
Source
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Retinoblastoma is the most frequent intraocular paediatric malignancy whose molecular basis remains poorly understood. Here, the authors perform multi-omic analysis and identify two subtypes; one in a cone differentiated state and one more aggressive showing cone dedifferentiation and expressing neuronal markers.