학술논문
Antimicrobial Use during the SARS-CoV-2 Pandemic in a Greek Tertiary University Hospital
Document Type
article
Author
Dimitrios Biros; Sempastian Filippas-Ntekouan; Diamantina Limperatou; Angelos Liontos; Rafail Matzaras; Konstantina-Helen Tsarapatsani; Nikolaos-Gavriel Kolios; Christiana Pappa; Maria Nasiou; Eleni Pargana; Ilias Tsiakas; Valentini Samanidou; Lazaros Athanasiou; Revekka Konstantopoulou; Haralampos Milionis; Eirini Christaki
Source
Microorganisms, Vol 12, Iss 3, p 623 (2024)
Subject
Language
English
ISSN
2076-2607
Abstract
In cases of SARS-CoV-2 hospitalization, despite low bacterial co-infection rates, antimicrobial use may be disproportionately high. Our aim was to quantify such usage in COVID-19 patients and identify factors linked to increased antibiotic use. We retrospectively studied patients with SARS-CoV-2 infection who were hospitalized at our institution during the pandemic. In the initial two waves of the pandemic, antimicrobial use was notably high (89% in the first wave and 92% in the second), but it decreased in subsequent waves. Elevated procalcitonin (>0.5 μg/mL) and C-reactive protein (>100 mg/L) levels were linked to antibiotic usage, while prior vaccination reduced antibiotic incidence. Antimicrobial use decreased in the pandemic, suggesting enhanced comprehension of SARS-CoV-2′s natural course. Additionally, it was correlated with heightened SARS-CoV-2 severity, elevated procalcitonin, and C-reactive protein levels.