학술논문

Next-generation vaccines for tropical infectious diseases
Document Type
article
Source
International Journal of Infectious Diseases, Vol 143, Iss , Pp 107014- (2024)
Subject
Infectious disease
Pathogen
Therapy
Vaccine
Lifecycle
Neglected
Infectious and parasitic diseases
RC109-216
Language
English
ISSN
1201-9712
Abstract
Tropical infectious diseases inflict an unacceptable burden of disease on humans living in developing countries. Although anti-pathogenic drugs have been widely used, they carry a constant threat of selecting for resistance. Vaccines offer a promising means by which to enhance the global control of tropical infectious diseases; however, these have been difficult to develop, mostly because of the complex nature of the pathogen lifecycles. Here, we present recently developed vaccine candidates for five tropical infectious diseases in the form of a catalog that have either entered clinical trials or have been licensed for use. We deliberate on recently licensed dengue vaccines, provide evidence why combination vaccination could have a synergistic impact on schistosomiasis, critically appraise the value of typhoid conjugate vaccines, and discuss the potential of vaccines in the efforts to eliminate vivax malaria and hookworms.