학술논문
Childhood depression and oxidative stress
Document Type
article
Source
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 58, Iss 1, Pp 1-9 (2022)
Subject
Language
English
ISSN
1687-8329
Abstract
Abstract Background Oxidative stress is a contributing factor in the etiopathogenesis of major depressive disorder (MDD). Pediatric studies regarding MDD-oxidative stress relationship are insufficient. In this study, we aimed to compare oxidative stress parameters of pediatric MDD patients with those of the control group and to examine factors affecting these parameters. Results Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), malondialdehyde (MDA) and superoxide dismutase (SOD) activities of 42 patients with MDD and 38 healthy controls were evaluated. Children depression inventory (CDI) was applied to all participants. In the MDD group, serum levels of TOS, OSI and MDA were higher, while TAS and SOD levels were lower (p