학술논문
Different inflammatory blood markers correlate with specific outcomes in incident HPV-negative head and neck squamous cell carcinoma: a retrospective cohort study
Document Type
article
Author
Paolo Boscolo-Rizzo; Andrea D’Alessandro; Jerry Polesel; Daniele Borsetto; Margherita Tofanelli; Alberto Deganello; Michele Tomasoni; Piero Nicolai; Paolo Bossi; Giacomo Spinato; Anna Menegaldo; Andrea Ciorba; Stefano Pelucchi; Chiara Bianchini; Diego Cazzador; Giulia Ramaciotti; Valentina Lupato; Vittorio Giacomarra; Gabriele Molteni; Daniele Marchioni; Cristoforo Fabbris; Antonio Occhini; Giulia Bertino; Jonathan Fussey; Giancarlo Tirelli
Source
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Subject
Language
English
ISSN
1471-2407
Abstract
Abstract Background Inflammatory blood markers have been associated with oncological outcomes in several cancers, but evidence for head and neck squamous cell carcinoma (HNSCC) is scanty. Therefore, this study aims at investigating the association between five different inflammatory blood markers and several oncological outcomes. Methods This multi-centre retrospective analysis included 925 consecutive patients with primary HPV-negative HNSCC (median age: 68 years) diagnosed between April 2004 and June 2018, whose pre-treatment blood parameters were available. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), systemic inflammatory marker (SIM), and systemic immune-inflammation index (SII) were calculated; their associations with local, regional, and distant failure, disease-free survival (DFS), and overall survival (OS) was calculated. Results The median follow-up was 53 months. All five indexes were significantly associated with OS; the highest accuracy in predicting patients’ survival was found for SIM (10-year OS = 53.2% for SIM