학술논문
Therapeutic hypothermia for neonatal encephalopathy with sepsis: a retrospective cohort study
Document Type
article
Author
Kei Lui; Victor Samuel Rajadurai; Malcolm Battin; lex Doyle; Leah Hickey; Srinivas Bolisetty; Peter Schmidt; Andy Gill; Jane Pillow; Jacqueline Stack; Pita Birch; Dan Casalaz; Jim Holberton; Alice Stewart; Lucy Cooke; Lyn Downe; Michael Stewart; Andrew Berry; Rod Hunt; Tony De Paoli; Mary Paradisis; Pieter Koorts; Carl Kuschel; Andrew Numa; Hazel Carlisle; Nadia Badawi; Guan Koh; Jonathan Davis; Melissa Luig; Chad Andersen; Brian Darlow; Liza Edmonds; Mariam Buksh; Georgina Chambers; Clare Collins; David Barker; Denise Harrison; Steven Resnick; Jutta van den Boom; Peter Morris; Rebecca Thomas; Mary Sharp; Naomi Spotswood; M Battin; Scott Morris; Nicola Austin; Michael Stark; Anjali Dhawan; Larissa Korostenski; Karen Nothdurft; Mark Greenhalgh; John Craven; Himanshu Popat; Bevan Headley; Barbara Hammond; Kristina Sibbin; Tara M Crawford; Guy Bloomfield; Callum Gately; Natalie Merida
Source
BMJ Paediatrics Open, Vol 6, Iss 1 (2022)
Subject
Language
English
ISSN
2022-0014
2399-9772
2399-9772
Abstract
Objective Neonatal encephalopathy remains a major cause of infant mortality and neurodevelopmental impairment. Infection may exacerbate brain injury and mitigate the effect of therapeutic hypothermia (TH). Additionally, infants with sepsis treated with TH may be at increased risk of adverse effects. This study aimed to review the clinical characteristics and outcomes for infants with sepsis treated with TH.Design and setting Retrospective cohort study of infants treated with TH within Australia and New Zealand.Patients 1522 infants treated with TH, including 38 with culture-positive sepsis from 2014 to 2018.Intervention Anonymised retrospective review of data from Australian and New Zealand Neonatal Network. Infants with culture-positive sepsis within 48 hours were compared with those without sepsis.Main outcome measures Key outcomes include in-hospital mortality, intensive care support requirements and length of stay.Results Overall the rate of mortality was similar between the groups (13% vs 13%). Infants with sepsis received a higher rate of mechanical ventilation (89% vs 70%, p=0.01), high-frequency oscillatory ventilation (32% vs 13%, p=0.003) and inhaled nitric oxide for persistent pulmonary hypertension (38% vs 16%, p