학술논문
SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus
Document Type
article
Author
Emilie Branche; Ying-Ting Wang; Karla M. Viramontes; Joan M. Valls Cuevas; Jialei Xie; Fernanda Ana-Sosa-Batiz; Norazizah Shafee; Sascha H. Duttke; Rachel E. McMillan; Alex E. Clark; Michael N. Nguyen; Aaron F. Garretson; Jan J. Crames; Nathan J. Spann; Zhe Zhu; Jeremy N. Rich; Deborah H. Spector; Christopher Benner; Sujan Shresta; Aaron F. Carlin
Source
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Zika virus (ZIKV) infection suppresses the induction of dendritic cell (DC)-derived immunity, but the underlying mechanistical insights are still lacking. Here the authors show, using in vitro systems profiling of DC transcriptome and epigenome, that ZIKV specifically alters SREBP2-related expression of inflammation- and metabolism-related genes to modulate DC functions.