학술논문
A stress-induced cilium-to-PML-NB route drives senescence initiation
Document Type
article
Author
Source
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Exposure to irreparable stresses induces transient ciliogenesis, enabling communication with PML-NBs via a FBF1 pathway to trigger senescence in mammalian cells. Fbf1 ablation reduces senescence and associated health decline in mice, highlighting cilia as a promising senotherapy target.