학술논문
Molecular determinants of response to PD-L1 blockade across tumor types
Document Type
article
Author
Romain Banchereau; Ning Leng; Oliver Zill; Ethan Sokol; Gengbo Liu; Dean Pavlick; Sophia Maund; Li-Fen Liu; Edward Kadel; Nicole Baldwin; Suchit Jhunjhunwala; Dorothee Nickles; Zoe June Assaf; Daniel Bower; Namrata Patil; Mark McCleland; David Shames; Luciana Molinero; Mahrukh Huseni; Shomyseh Sanjabi; Craig Cummings; Ira Mellman; Sanjeev Mariathasan; Priti Hegde; Thomas Powles
Source
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
PD-L1 immune checkpoint inhibition has been used for several tumour types. Here, the authors use immunohistochemistry, tumour mutation burden and RNA-seq data from 366 patients with different indications to identify molecular signatures of response to atezolizumab and reveal pathway heterogeneity and the involvement of non-immune pathways.