학술논문
Computation of contrast-enhanced perfusion using only two CT scan phases: a proof-of-concept study on abdominal organs
Document Type
article
Author
Source
European Radiology Experimental, Vol 6, Iss 1, Pp 1-12 (2022)
Subject
Language
English
ISSN
2509-9280
Abstract
Abstract Background Computed tomography perfusion imaging (CTPI) by repeated scanning has clinical relevance but implies relatively high radiation exposure. We present a method to measure perfusion from two CT scan phases only, considering tissue enhancement, feeding vessel (aortic) peak enhancement, and bolus shape. Methods CTPI scans (each with 40 frames acquired every 1.5 s) of 11 patients with advanced hepatocellular carcinoma (HCC) enrolled between 2012 and 2016 were retrospectively analysed (aged 69 ± 9 years, 8/11 males). Perfusion was defined as the maximal slope of the time-enhancement curve divided by the peak enhancement of the feeding vessel (aorta). Perfusion was computed two times, first using the maximum slope derived from all data points and then using the peak tissue enhancement and the bolus shape obtained from the aortic curve. Results Perfusion values from the two methods were linearly related (r 2 = 0.92, p