학술논문
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
Document Type
article
Author
Jonas B. Nielsen; Oren Rom; Ida Surakka; Sarah E. Graham; Wei Zhou; Tanmoy Roychowdhury; Lars G. Fritsche; Sarah A. Gagliano Taliun; Carlo Sidore; Yuhao Liu; Maiken E. Gabrielsen; Anne Heidi Skogholt; Brooke Wolford; William Overton; Ying Zhao; Jin Chen; He Zhang; Whitney E. Hornsby; Akua Acheampong; Austen Grooms; Amanda Schaefer; Gregory J. M. Zajac; Luis Villacorta; Jifeng Zhang; Ben Brumpton; Mari Løset; Vivek Rai; Pia R. Lundegaard; Morten S. Olesen; Kent D. Taylor; Nicholette D. Palmer; Yii-Der Chen; Seung H. Choi; Steven A. Lubitz; Patrick T. Ellinor; Kathleen C. Barnes; Michelle Daya; Nicholas Rafaels; Scott T. Weiss; Jessica Lasky-Su; Russell P. Tracy; Ramachandran S. Vasan; L. Adrienne Cupples; Rasika A. Mathias; Lisa R. Yanek; Lewis C. Becker; Patricia A. Peyser; Lawrence F. Bielak; Jennifer A. Smith; Stella Aslibekyan; Bertha A. Hidalgo; Donna K. Arnett; Marguerite R. Irvin; James G. Wilson; Solomon K. Musani; Adolfo Correa; Stephen S. Rich; Xiuqing Guo; Jerome I. Rotter; Barbara A. Konkle; Jill M. Johnsen; Allison E. Ashley-Koch; Marilyn J. Telen; Vivien A. Sheehan; John Blangero; Joanne E. Curran; Juan M. Peralta; Courtney Montgomery; Wayne H-H Sheu; Ren-Hua Chung; Karen Schwander; Seyed M. Nouraie; Victor R. Gordeuk; Yingze Zhang; Charles Kooperberg; Alexander P. Reiner; Rebecca D. Jackson; Eugene R. Bleecker; Deborah A. Meyers; Xingnan Li; Sayantan Das; Ketian Yu; Jonathon LeFaive; Albert Smith; Tom Blackwell; Daniel Taliun; Sebastian Zollner; Lukas Forer; Sebastian Schoenherr; Christian Fuchsberger; Anita Pandit; Matthew Zawistowski; Sachin Kheterpal; Chad M. Brummett; Pradeep Natarajan; David Schlessinger; Seunggeun Lee; Hyun Min Kang; Francesco Cucca; Oddgeir L. Holmen; Bjørn O. Åsvold; Michael Boehnke; Sekar Kathiresan; Goncalo R. Abecasis; Y. Eugene Chen; Cristen J. Willer; Kristian Hveem
Source
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Drugs targeting cardiovascular disease (CVD) can have negative consequences for liver function. Here, the authors combine genome wide analyses on 69,479 individuals to identify loss-of-function variants with beneficial effects on CVD-related traits without negative impacts on liver function.