학술논문
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Document Type
article
Author
Tuomas O. Kilpeläinen; Amy R. Bentley; Raymond Noordam; Yun Ju Sung; Karen Schwander; Thomas W. Winkler; Hermina Jakupović; Daniel I. Chasman; Alisa Manning; Ioanna Ntalla; Hugues Aschard; Michael R. Brown; Lisa de las Fuentes; Nora Franceschini; Xiuqing Guo; Dina Vojinovic; Stella Aslibekyan; Mary F. Feitosa; Minjung Kho; Solomon K. Musani; Melissa Richard; Heming Wang; Zhe Wang; Traci M. Bartz; Lawrence F. Bielak; Archie Campbell; Rajkumar Dorajoo; Virginia Fisher; Fernando P. Hartwig; Andrea R. V. R. Horimoto; Changwei Li; Kurt K. Lohman; Jonathan Marten; Xueling Sim; Albert V. Smith; Salman M. Tajuddin; Maris Alver; Marzyeh Amini; Mathilde Boissel; Jin Fang Chai; Xu Chen; Jasmin Divers; Evangelos Evangelou; Chuan Gao; Mariaelisa Graff; Sarah E. Harris; Meian He; Fang-Chi Hsu; Anne U. Jackson; Jing Hua Zhao; Aldi T. Kraja; Brigitte Kühnel; Federica Laguzzi; Leo-Pekka Lyytikäinen; Ilja M. Nolte; Rainer Rauramaa; Muhammad Riaz; Antonietta Robino; Rico Rueedi; Heather M. Stringham; Fumihiko Takeuchi; Peter J. van der Most; Tibor V. Varga; Niek Verweij; Erin B. Ware; Wanqing Wen; Xiaoyin Li; Lisa R. Yanek; Najaf Amin; Donna K. Arnett; Eric Boerwinkle; Marco Brumat; Brian Cade; Mickaël Canouil; Yii-Der Ida Chen; Maria Pina Concas; John Connell; Renée de Mutsert; H. Janaka de Silva; Paul S. de Vries; Ayşe Demirkan; Jingzhong Ding; Charles B. Eaton; Jessica D. Faul; Yechiel Friedlander; Kelley P. Gabriel; Mohsen Ghanbari; Franco Giulianini; Chi Charles Gu; Dongfeng Gu; Tamara B. Harris; Jiang He; Sami Heikkinen; Chew-Kiat Heng; Steven C. Hunt; M. Arfan Ikram; Jost B. Jonas; Woon-Puay Koh; Pirjo Komulainen; Jose E. Krieger; Stephen B. Kritchevsky; Zoltán Kutalik; Johanna Kuusisto; Carl D. Langefeld; Claudia Langenberg; Lenore J. Launer; Karin Leander; Rozenn N. Lemaitre; Cora E. Lewis; Jingjing Liang; Lifelines Cohort Study; Jianjun Liu; Reedik Mägi; Ani Manichaikul; Thomas Meitinger; Andres Metspalu; Yuri Milaneschi; Karen L. Mohlke; Thomas H. Mosley; Alison D. Murray; Mike A. Nalls; Ei-Ei Khaing Nang; Christopher P. Nelson; Sotoodehnia Nona; Jill M. Norris; Chiamaka Vivian Nwuba; Jeff O’Connell; Nicholette D. Palmer; George J. Papanicolau; Raha Pazoki; Nancy L. Pedersen; Annette Peters; Patricia A. Peyser; Ozren Polasek; David J. Porteous; Alaitz Poveda; Olli T. Raitakari; Stephen S. Rich; Neil Risch; Jennifer G. Robinson; Lynda M. Rose; Igor Rudan; Pamela J. Schreiner; Robert A. Scott; Stephen S. Sidney; Mario Sims; Jennifer A. Smith; Harold Snieder; Tamar Sofer; John M. Starr; Barbara Sternfeld; Konstantin Strauch; Hua Tang; Kent D. Taylor; Michael Y. Tsai; Jaakko Tuomilehto; André G. Uitterlinden; M. Yldau van der Ende; Diana van Heemst; Trudy Voortman; Melanie Waldenberger; Patrik Wennberg; Gregory Wilson; Yong-Bing Xiang; Jie Yao; Caizheng Yu; Jian-Min Yuan; Wei Zhao; Alan B. Zonderman; Diane M. Becker; Michael Boehnke; Donald W. Bowden; Ulf de Faire; Ian J. Deary; Paul Elliott; Tõnu Esko; Barry I. Freedman; Philippe Froguel; Paolo Gasparini; Christian Gieger; Norihiro Kato; Markku Laakso; Timo A. Lakka; Terho Lehtimäki; Patrik K. E. Magnusson; Albertine J. Oldehinkel; Brenda W. J. H. Penninx; Nilesh J. Samani; Xiao-Ou Shu; Pim van der Harst; Jana V. Van Vliet-Ostaptchouk; Peter Vollenweider; Lynne E. Wagenknecht; Ya X. Wang; Nicholas J. Wareham; David R. Weir; Tangchun Wu; Wei Zheng; Xiaofeng Zhu; Michele K. Evans; Paul W. Franks; Vilmundur Gudnason; Caroline Hayward; Bernardo L. Horta; Tanika N. Kelly; Yongmei Liu; Kari E. North; Alexandre C. Pereira; Paul M. Ridker; E. Shyong Tai; Rob M. van Dam; Ervin R. Fox; Sharon L. R. Kardia; Ching-Ti Liu; Dennis O. Mook-Kanamori; Michael A. Province; Susan Redline; Cornelia M. van Duijn; Jerome I. Rotter; Charles B. Kooperberg; W. James Gauderman; Bruce M. Psaty; Kenneth Rice; Patricia B. Munroe; Myriam Fornage; L. Adrienne Cupples; Charles N. Rotimi; Alanna C. Morrison; Dabeeru C. Rao; Ruth J. F. Loos
Source
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.