학술논문
Peripheral and lung resident memory T cell responses against SARS-CoV-2
Document Type
article
Author
Judith Grau-Expósito; Nerea Sánchez-Gaona; Núria Massana; Marina Suppi; Antonio Astorga-Gamaza; David Perea; Joel Rosado; Anna Falcó; Cristina Kirkegaard; Ariadna Torrella; Bibiana Planas; Jordi Navarro; Paula Suanzes; Daniel Álvarez-Sierra; Alfonso Ayora; Irene Sansano; Juliana Esperalba; Cristina Andrés; Andrés Antón; Santiago Ramón y Cajal; Benito Almirante; Ricardo Pujol-Borrell; Vicenç Falcó; Joaquín Burgos; María J. Buzón; Meritxell Genescà
Source
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Lung resident memory T (TRM) cells are important for protection from viral infection in the lungs. Here the authors use paired lung biopsy material and blood to characterize T cell responses in patients with COVID-19 over time and find persistence of antiviral lung TRM cells that might be important to limit reinfection.