학술논문
Anticancer properties of bromelain: State-of-the-art and recent trends
Document Type
article
Author
Raffaele Pezzani; Manuel Jiménez-Garcia; Xavier Capó; Eda Sönmez Gürer; Farukh Sharopov; Tchokouaha Yamthe Lauve Rachel; David Ntieche Woutouoba; Antonio Rescigno; Stefania Peddio; Paolo Zucca; Patrick Valere Tsouh Fokou; Miquel Martorell; Zehra Gulsunoglu-Konuskan; Alibek Ydyrys; Tynybekov Bekzat; Tussupbekova Gulmira; Christophe Hano; Javad Sharifi-Rad; Daniela Calina
Source
Frontiers in Oncology, Vol 12 (2023)
Subject
Language
English
ISSN
2234-943X
Abstract
Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases.